Maternal consumption of ultra-processed foods and subsequent risk of offspring overweight or obesity: results from three prospective cohort studies
BMJ 2022; 379 doi: https://doi.org/10.1136/bmj-2022-071767 (Published 05 October 2022) Cite this as: BMJ 2022;379:e071767
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Dear Editor,
According to the report by Wang and colleagues, excessive maternal consumption of ultra-processed food during the child-rearing period was associated with an increased risk of overweight or obesity in offspring [1]. One of the strengths of this study is to have adjusted for maternal and offspring's associated lifestyles with obesity longitudinally, which have suffered many previous cohort studies as serving major confounders. However, we would like to raise one issue about this discussion: is only excessive ultra-processed food an absolute evil?
In this study, the authors divided participants into five groups by the amount of maternal ultra-processed food consumption during the child-rearing period. Although the group with the highest maternal ultra-processed food consumption (Group 5) had a 26% increased risk of offspring's overweight/obesity compared to the group with the lowest consumption (Group 1), each remaining group (Group 2-4) did not have an increased risk statistically. In other words, the authors failed to present a dose-dependent relationship between the amount of maternal ultra-processed food consumption and offspring's overweight/obesity.
Off course, we agree with the opinion that excessive ultra-produced food consumption can play an essential role in offspring's overweight/obesity but interpret that moderate ultra-produced food consumption may not. We also suspect that the limitation of essential foods consumption due to excessive ultra-produced food consumption may result in offspring's overweight/obesity in this situation. From this perspective, we are afraid that the "universal" ultra-produced food regulation strategy may have limited effects on the prevention of offspring's overweight/obesity. Therefore, further studies seem warranted to specify the optimal target of the ultra-produced food regulation strategy to promote offspring's health.
References
1. Wang Y, Wang K, Du M, et al. Maternal consumption of ultra-processed foods and subsequent risk of offspring overweight or obesity: results from three prospective cohort studies. BMJ 2022;379:e071767. doi:10.1136/bmj-2022-071767 pmid:36198411
Competing interests: No competing interests
Dear Editor
This article focuses on the matter of ultra-processed food (UPF) consumption, which is crucial for preventing chronic diseases from a global health perspective, but the conclusion could be affected by the selection of the study population.
“Blurred criteria of the study population”
The design focuses on food categorization and the details of the diet of the pregnancy, but there are also other papers suggesting a strong association between the mode of delivery and the child’s body mass index throughout the offspring’s life to adulthood [1].
“Both parents’ weight condition might be affecting the results of this study”
The result of this article was the association of UPF and overweight among the offspring, the study population however was just about the mothers, neglecting the father’s role in the pregnancy. There are papers proving that both parents’ overweight condition can have consequences in the combination of the sperm and oocytes leading to unhealthy offspring [2].
“Diseases during the pregnancy could be affecting the infant’s overweight condition”
There are also papers stating that gestational hypertension, gestational diabetes mellitus, and smoking during pregnancy can also have effects associated with the infant’s overweight condition [3].
In conclusion, the study of UPF’s relationship with offspring’s overweight or obesity has profound implications since food nutrition is a crucial part of the epidemiological transition for global health. Therefore, a carefully designed epidemiological study is essential, slight mistakes could be misleading the interventions emerging from the conclusions of the study. Further study could be implemented this conclusion in animal trials to prove its effectiveness.
1 Darmasseelane, K., Hyde, M. J., Santhakumaran, S., Gale, C. & Modi, N. Mode of delivery and offspring body mass index, overweight and obesity in adult life: a systematic review and meta-analysis. PloS one 9, e87896 (2014).
2 Hieronimus, B. & Ensenauer, R. Influence of maternal and paternal pre-conception overweight/obesity on offspring outcomes and strategies for prevention. European Journal of Clinical Nutrition 75, 1735-1744 (2021).
3 Yu, Z. et al. Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis. PloS one 8, e61627 (2013).
Competing interests: No competing interests
Discussion of some questions in the article and personal views on ultra-processed foods
Dear Editor:
With great interest, I read the recent research paper by Wang and his colleagues on Maternal consumption of ultra-processed foods and subsequent risk of offspring overweight or obesity: results from three prospective cohort studies[1]. As a graduate student in the global health major, I firmly endorse their point of view, thus limiting the consumption of ultra-processed foods by mothers and women of childbearing age can reduce the risk of children becoming overweight. And we should not ignore the social determinants of health that may prevent women from reducing their intake of ultra-processed foods. As a global citizen concerned with sociology who takes heed of social anxiety about food safety and desire for natural foods, I am writing to bring to the public’s attention the seriousness of such a phenomenon.
The paper provided solid evidence on albeit already ample scruple of whether long-term consumption of overly processed foods can have substantial health effects. Following the momentum, I searched lots of related information. A British study shows similar studies have been done on ultra-processed foods and chronic noncommunicable diseases[2]. In the process of comparing and reading the two articles, I found some problems that confused me. Here I would like to discuss them with you.
1. There is a subtle difference between the statistics of height and weight. Height can only increase or stay the same over time, but weight may fluctuate between the two statistical intervals. Whether there are children who are overweight during the time period and are not counted, it will have a certain impact on the final results.
2. There is a large portion of compound foods in the food category, which are composed of two or more single foods mixed together. The article does not appear to address dishes that do not clearly identify their main ingredients, or how non-caloric supplements are classified. This omission may affect the consumption statistics of ultra-processed foods.
Some time ago, a blogger's live broadcast of homemade ultra-processed food made with chemicals sparked a heated debate on the Chinese Internet[3]. This article directly quantifies the potential health effects of ultra-processed foods and responds to social concerns about food safety. In this social environment, I would like to share some ideas on the popular demand for ultra-processed foods.
Pay special attention to special groups (e.g., Pregnant women, infants, patients with chronic diseases, the elderly, etc);
Food types are transparent and labeled;
Cooking methods and additive measurements are strictly regulated;
Improve the nutritional value of ultra-processed foods and increase their competitiveness.
In summary, there are complex social issues behind frequent consumption of ultra-processed foods. In the case of China, the current strict outbreak control regime has made it difficult to access natural foods, both economically and logistically. I believe that ultra-processed food may become the main source of food for a certain group under special social circumstances, and how to ensure food quality and strive to achieve health equity is the focus of the present.
1. Wang Y, Wang K, Du M, Khandpur N, Rossato S L, Lo C et al. Maternal consumption of ultra-processed foods and subsequent risk of offspring overweight or obesity: results from three prospective cohort studies BMJ 2022; 379 :e071767 doi:10.1136/bmj-2022-071767
2. Rauber, F., da Costa Louzada, M. L., Steele, E. M., Millett, C., Monteiro, C. A., & Levy, R. B. (2018). Ultra-Processed Food Consumption and Chronic Non-Communicable Diseases-Related Dietary Nutrient Profile in the UK (2008⁻2014). Nutrients, 10(5), 587. https://doi.org/10.3390/nu10050587
3. Rui, Z. (2022, October 6). A Blogger Who Exposed China’s Notorious Food Technology: Tiktok Has Been Banned. rfa 2022.10.06.
Competing interests: No competing interests