Re: Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank
Have these conclusions been verified by other researchers? It is surprising when considering the immense significance of these conclusions that others have not made similar conclusions. Let me explain my concerns with the study conclusions.
The biomedical parameters of most, if not all, diabetics is that their condition is accompanied by lower pH (from the normal level of ca 7.35-7.45 to below pH7, perhaps as low as 6.50) ie elevated levels of intercellular acidity which influences the prevailing levels of essential minerals eg Mg, Ca, Zn, Cr; and non-essential heavy metals eg Fe, Al, Hg, etc. As acidity increases the levels and bioavailability of essential minerals declines whilst the levels of nonessential minerals increases (and is associated with the free radical reactions catalysed by heavy metals which accompany pathological onset). This is particularly evident in the diabetic where type 2 diabetes is accompanied by lower levels of magnesium, lower levels and/or biovailability of zinc, elevated levels of iron and heavy metals, etc.
The issue is often observed in long distance runners who can develop anaemia as a result of overexercising ie their blood pH becomes so high as a result of eliminating CO2 and minimising body fat that it is unable to retain adequate levels of iron and hence of haemoglobin. This is basic chemistry. It explains how for example someone who consumes alcoholic and/or acidic beverages would become deficient in essential minerals, why someone who drinks colas would become deficient in magnesium (and perhaps other essential minerals) and why the overweight and diabetic have lower levels of essential minerals and higher levels of iron and other nonessential minerals. The degree of demineralisation of essential minerals depends upon the nature and extent of the acidity e.g. if as phosphoric acid, acetic acid, or other.
Accordingly I question the conclusions made in this study that the genetic indications identified are in fact associated with levels of iron. If considering diabetic patients the study will inevitably note higher levels of iron in the diabetic patients however this does not necessarily mean that the elevated levels of iron have the genetic origins identified in the conclusions of this study.
Ewing GW. Is Metformin a Drug or a Buffer and Why is this Significant? Further evidence that the brain Regulates the Autonomic Nervous System, in particular prevailing levels of Intercellular pH. Endocrinology, Diabetes and Metabolism Journal (EDMJ) 2018;2(4):1-9.
Ewing GW. The Regulation of pH is a Physiological System. Increased Acidity alters Protein Conformation and Cell Morphology and is a Significant Factor in the onset of Diabetes and other common pathologies. The Open Systems Biology Journal 2012;5:1-12.
Rapid Response:
Re: Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank
Have these conclusions been verified by other researchers? It is surprising when considering the immense significance of these conclusions that others have not made similar conclusions. Let me explain my concerns with the study conclusions.
The biomedical parameters of most, if not all, diabetics is that their condition is accompanied by lower pH (from the normal level of ca 7.35-7.45 to below pH7, perhaps as low as 6.50) ie elevated levels of intercellular acidity which influences the prevailing levels of essential minerals eg Mg, Ca, Zn, Cr; and non-essential heavy metals eg Fe, Al, Hg, etc. As acidity increases the levels and bioavailability of essential minerals declines whilst the levels of nonessential minerals increases (and is associated with the free radical reactions catalysed by heavy metals which accompany pathological onset). This is particularly evident in the diabetic where type 2 diabetes is accompanied by lower levels of magnesium, lower levels and/or biovailability of zinc, elevated levels of iron and heavy metals, etc.
The issue is often observed in long distance runners who can develop anaemia as a result of overexercising ie their blood pH becomes so high as a result of eliminating CO2 and minimising body fat that it is unable to retain adequate levels of iron and hence of haemoglobin. This is basic chemistry. It explains how for example someone who consumes alcoholic and/or acidic beverages would become deficient in essential minerals, why someone who drinks colas would become deficient in magnesium (and perhaps other essential minerals) and why the overweight and diabetic have lower levels of essential minerals and higher levels of iron and other nonessential minerals. The degree of demineralisation of essential minerals depends upon the nature and extent of the acidity e.g. if as phosphoric acid, acetic acid, or other.
Accordingly I question the conclusions made in this study that the genetic indications identified are in fact associated with levels of iron. If considering diabetic patients the study will inevitably note higher levels of iron in the diabetic patients however this does not necessarily mean that the elevated levels of iron have the genetic origins identified in the conclusions of this study.
Ewing GW. Is Metformin a Drug or a Buffer and Why is this Significant? Further evidence that the brain Regulates the Autonomic Nervous System, in particular prevailing levels of Intercellular pH. Endocrinology, Diabetes and Metabolism Journal (EDMJ) 2018;2(4):1-9.
Ewing GW. The Regulation of pH is a Physiological System. Increased Acidity alters Protein Conformation and Cell Morphology and is a Significant Factor in the onset of Diabetes and other common pathologies. The Open Systems Biology Journal 2012;5:1-12.
Competing interests: No competing interests