Letters
BCG vaccination and TB in children
No proof that BCG protects against infection with Mycobacterium tuberculosis
BMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g5436 (Published 10 September 2014) Cite this as: BMJ 2014;349:g5436
- Richard Turner, clinical research fellow, respiratory medicine1,
- Conor Tweed, clinical research fellow, respiratory medicine1,
- Graham Bothamley, honorary professor and consultant physician1
- 1Homerton University Hospital, London E9 6SR, UK
- richard.turner{at}homerton.nhs.uk
BCG protects against primary tuberculosis, but evidence for protection against infection with Mycobacterium tuberculosis remains controversial. Roy and colleagues merely showed that previous BCG vaccination is associated with a reduced frequency of positive interferon γ release assay (IGRA) results in children recently exposed to M tuberculosis.1
A positive IGRA response indicates a previous interaction with M tuberculosis sufficient to lead to …
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